ELK3

ELK3
Identifiers
Aliases	ELK3, ERP, NET, SAP2, SAP-2, ETS transcription factor, ETS transcription factor ELK3
External IDs	OMIM: 600247; MGI: 101762; HomoloGene: 3833; GeneCards: ELK3; OMA:ELK3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	96,269,824 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	93,146,997 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; synovial joint; ; amniotic fluid; ; urethra; ; visceral pleura; ; vena cava; ; parietal pleura; ; oral cavity; ; mucosa of paranasal sinus; ; superficial temporal artery;
	Top expressed in
	endothelial cell of lymphatic vessel; ; dermis; ; endocardial cushion; ; left lung lobe; ; atrioventricular valve; ; atrium; ; external carotid artery; ; decidua; ; vas deferens; ; semi-lunar valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; transcription corepressor activity; purine-rich negative regulatory element binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific;
Cellular component	mitochondrion; nucleoplasm; cytoplasm; nucleus;
Biological process	transcription, DNA-templated; cell differentiation; wound healing; regulation of transcription, DNA-templated; angiogenesis; signal transduction; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2004
	13713
	ENSG00000111145
	ENSMUSG00000008398
	P41970
	P41971
	NM_001303511; NM_005230
	NM_001282967; NM_013508; NM_205536; NM_001322265; NM_001322268
	NP_001290440; NP_005221
	NP_001269896; NP_001309194; NP_001309197; NP_038536
	Wikidata
View/Edit Human	View/Edit Mouse

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.