ELMO2

ELMO2
Identifiers
Aliases	ELMO2, CED-12, CED12, ELMO-2, Ced-12A, engulfment and cell motility 2, VMPI
External IDs	OMIM: 606421; MGI: 2153045; HomoloGene: 44338; GeneCards: ELMO2; OMA:ELMO2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	46,432,985 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	165,168,399 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; cerebellar vermis; ; caudate nucleus; ; granulocyte; ; right frontal lobe; ; nucleus accumbens; ; putamen; ; C1 segment; ; Amygdala;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; visual cortex; ; primary visual cortex; ; superior frontal gyrus; ; cerebellar cortex; ; lobe of cerebellum; ; genital tubercle; ; cerebellar vermis; ; tail of embryo; ; piriform cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; receptor tyrosine kinase binding; protein binding;
Cellular component	cytosol; membrane; cytoplasm;
Biological process	cell chemotaxis; vascular endothelial growth factor receptor signaling pathway; cell-cell adhesion; cell migration; cytoskeleton organization; Fc-gamma receptor signaling pathway involved in phagocytosis; phagocytosis; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	63916
	140579
	ENSG00000062598
	ENSMUSG00000017670
	Q96JJ3; Q5JVZ4
	Q8BHL5
	NM_022086; NM_133171; NM_182764; NM_001318253
NM_080287; NM_207705; NM_207706; NM_001302752; NM_001302754;
	NM_207704
	NP_001305182; NP_573403; NP_877496
	NP_001289681; NP_001289683; NP_525026; NP_997589
	Wikidata
View/Edit Human	View/Edit Mouse

Engulfment and cell motility protein 2 is a protein that in humans is encoded by the ELMO2 gene.

The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants encoding the same protein.