EMR1

ADGRE1
Identifiers
Aliases	ADGRE1, TM7LN3, EMR1, adhesion G protein-coupled receptor E1
External IDs	OMIM: 600493; MGI: 106912; HomoloGene: 1493; GeneCards: ADGRE1; OMA:ADGRE1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,940,459 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,790,527 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; testicle; ; spleen; ; bone marrow; ; appendix; ; right lung; ; bone marrow cells; ; palpebral conjunctiva;
	Top expressed in
	stroma of bone marrow; ; muscle layer of urethra; ; calvaria; ; granulocyte; ; mesenteric lymph nodes; ; lamina propria of urethra; ; spleen; ; right ventricle; ; tibiofemoral joint; ; ankle joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; external side of plasma membrane; cell periphery; intracellular anatomical structure;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; cell adhesion; adaptive immune response; signal transduction; immune system process; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2015
	13733
	ENSG00000174837
	ENSMUSG00000004730
	Q14246
	Q61549
	NM_001256252; NM_001256253; NM_001256254; NM_001256255; NM_001974
	NM_010130; NM_001355722; NM_001355723
	NP_001243181; NP_001243182; NP_001243183; NP_001243184; NP_001965
	NP_034260; NP_001342651; NP_001342652
	Wikidata
View/Edit Human	View/Edit Mouse

EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene.

EMR1 is a member of the adhesion GPCR family characterized by an extended extracellular region containing EGF-like domains. EMR1 is predominantly expressed on the surface of macrophages and plays a significant role in immune response modulation and inflammation. Its expression has been linked to various inflammatory diseases.