EMR2

ADGRE2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2BOX, 2BO2, 2BOU
Identifiers
Aliases	ADGRE2, CD312, VBU, EMR2, adhesion G protein-coupled receptor E2, CD97
External IDs	OMIM: 606100; HomoloGene: 113735; GeneCards: ADGRE2; OMA:ADGRE2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,778,560 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; spleen; ; appendix; ; periodontal fiber; ; upper lobe of left lung; ; palpebral conjunctiva; ; right lung; ; gallbladder;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; chondroitin sulfate binding; transmembrane signaling receptor activity; signal transducer activity; G protein-coupled receptor activity;
Cellular component	ruffle membrane; plasma membrane; cell projection; membrane; leading edge membrane; integral component of membrane; intracellular anatomical structure; integral component of plasma membrane;
Biological process	cell surface receptor signaling pathway; inflammatory response; cell migration; granulocyte chemotaxis; signal transduction; G protein-coupled receptor signaling pathway; cell adhesion; regulation of mast cell degranulation; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	30817
	n/a
	ENSG00000127507
	n/a
	Q9UHX3
	n/a
NM_001271052; NM_013447; NM_152916; NM_152917; NM_152918;
	NM_152919; NM_152920; NM_152921
	n/a
	NP_001257981; NP_038475
	n/a
	Wikidata
View/Edit Human

EGF-like module-containing mucin-like hormone receptor-like 2 also known as CD312 (cluster of differentiation 312) is a protein encoded by the ADGRE2 gene. EMR2 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

EMR2 is expressed by monocytes/macrophages, dendritic cells and all types of granulocytes. In the case of EMR2 the N-terminal domains consist of alternatively spliced epidermal growth factor-like (EGF-like) domains. EMR2 is closely related to CD97 with 97% amino-acid identity in the EGF-like domains. The N-terminal fragment (NTF) of EMR2 presents 2-5 EGF-like domains in human. Mice lack the Emr2 gene. This gene is closely linked to the gene encoding EGF-like molecule containing mucin-like hormone receptor 3 EMR3 on chromosome 19.