ENDOG

ENDOG
Identifiers
Aliases	ENDOG, endonuclease G
External IDs	OMIM: 600440; MGI: 1261433; HomoloGene: 55823; GeneCards: ENDOG; OMA:ENDOG - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	128,822,676 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	30,064,081 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; apex of heart; ; gastrocnemius muscle; ; triceps brachii muscle; ; body of tongue; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; thoracic diaphragm; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	right ventricle; ; digastric muscle; ; myocardium of ventricle; ; masseter muscle; ; sternocleidomastoid muscle; ; soleus muscle; ; extraocular muscle; ; temporal muscle; ; right kidney; ; tibialis anterior muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	deoxyribonuclease activity; metal ion binding; protein binding; nucleic acid binding; nuclease activity; endonuclease activity; hydrolase activity; single-stranded DNA endodeoxyribonuclease activity; endoribonuclease activity; exodeoxyribonuclease activity;
Cellular component	cytosol; perikaryon; mitochondrion; nucleus; mitochondrial inner membrane;
Biological process	cellular response to calcium ion; positive regulation of apoptotic DNA fragmentation; DNA recombination; apoptotic DNA fragmentation; response to estradiol; response to antibiotic; response to mechanical stimulus; ageing; in utero embryonic development; response to tumor necrosis factor; neuron death in response to oxidative stress; positive regulation of apoptotic process; cellular response to oxidative stress; cellular response to hypoxia; cellular response to glucose stimulus; positive regulation of hydrogen peroxide-mediated programmed cell death; DNA catabolic process, endonucleolytic; RNA phosphodiester bond hydrolysis, endonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	2021
	13804
	ENSG00000167136
	ENSMUSG00000015337
	Q14249
	O08600
	NM_004435
	NM_007931
	NP_004426
	NP_031957
	Wikidata
View/Edit Human	View/Edit Mouse

Endonuclease G, mitochondrial is an enzyme that in humans is encoded by the ENDOG gene. This protein primarily participates in caspase-independent apoptosis via DNA degradation when translocating from the mitochondrion to nucleus under oxidative stress. As a result, EndoG has been implicated in cancer, aging, and neurodegenerative diseases such as Parkinson's disease (PD). Regulation of its expression levels thus holds potential to treat or ameliorate those conditions.