Enolase 2

ENO2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TE6, 2AKM, 2AKZ, 3UCC, 3UCD, 3UJE, 3UJF, 3UJR, 3UJS, 4ZCW, 4ZA0
Identifiers
Aliases	ENO2, HEL-S-279, NSE, Enolase 2
External IDs	OMIM: 131360; MGI: 95394; HomoloGene: 74414; GeneCards: ENO2; OMA:ENO2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,923,698 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,746,636 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; paraflocculus of cerebellum; ; cerebellar vermis; ; Brodmann area 10; ; right frontal lobe; ; frontal pole; ; Brodmann area 9; ; postcentral gyrus; ; cingulate gyrus;
	Top expressed in
	motor neuron; ; pontine nuclei; ; cerebellar cortex; ; subiculum; ; superior frontal gyrus; ; dorsomedial hypothalamic nucleus; ; dentate gyrus of hippocampal formation granule cell; ; superior colliculus; ; primary motor cortex; ; lateral geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; lyase activity; magnesium ion binding; phosphopyruvate hydratase activity;
Cellular component	cytoplasm; cytosol; plasma membrane; phosphopyruvate hydratase complex; extracellular exosome; extracellular space; membrane; photoreceptor inner segment; soma; perikaryon; intracellular anatomical structure; myelin sheath;
Biological process	gluconeogenesis; canonical glycolysis; glycolytic process;
	Sources:Amigo / QuickGO
Orthologs
	2026
	13807
	ENSG00000111674
	ENSMUSG00000004267
	P09104; Q6FHV6
	P17183
	NM_001975
	NM_013509; NM_001302642; NM_001355220
	NP_001966; NP_001966.1
	NP_001289571; NP_038537; NP_001342149
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene. Gamma-enolase is a phosphopyruvate hydratase.

Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.