ENOX2

ENOX2
Identifiers
Aliases	ENOX2, APK1, COVA1, tNOX, ecto-NOX disulfide-thiol exchanger 2
External IDs	OMIM: 300282; MGI: 2384799; HomoloGene: 17120; GeneCards: ENOX2; OMA:ENOX2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	130,903,234 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	48,377,136 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; gonad; ; tendon of biceps brachii; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; left coronary artery; ; testicle; ; thoracic aorta; ; monocyte;
	Top expressed in
	habenula; ; interventricular septum; ; Paneth cell; ; otic vesicle; ; muscle of thigh; ; trigeminal ganglion; ; sciatic nerve; ; saccule; ; substantia nigra; ; ventricular zone;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein-disulfide reductase activity; oxidoreductase activity; protein binding; nucleic acid binding; RNA binding;
Cellular component	extracellular region; cytosol; plasma membrane; membrane; external side of plasma membrane; extracellular space;
Biological process	cell growth; regulation of growth; ultradian rhythm; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	10495
	209224
	ENSG00000165675
	ENSMUSG00000031109
	Q16206
	Q8R0Z2
NM_001281736; NM_006375; NM_182314; NM_001382516; NM_001382517;
	NM_001382518; NM_001382519; NM_001382520; NM_001382521; NM_001382522
NM_001271447; NM_001271448; NM_001271449; NM_001271450; NM_001271451;
	NM_145951
NP_001268665; NP_006366; NP_872114; NP_001369445; NP_001369446;
	NP_001369447; NP_001369448; NP_001369449; NP_001369450; NP_001369451
NP_001258376; NP_001258377; NP_001258378; NP_001258379; NP_001258380;
	NP_666063
	Wikidata
View/Edit Human	View/Edit Mouse

ENOX2 is a gene located on the long arm of the X chromosome in humans. The gene encodes the protein Ecto-NOX disulfide-thiol exchanger 2, a member of the NOX family of NADPH oxidases.

Ecto-NOX disulfide-thiol exchanger 2 is a growth-related cell surface protein. It was identified because it reacts with the monoclonal antibody K1 in cells, such as the ovarian carcinoma line OVCAR-3, also expressing the CAKI surface glycoprotein. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The two activities alternate with a period length of about 24 minutes. The encoded protein also displays prion-like properties. Two transcript variants encoding different isoforms have been found for this gene.