ENTPD2

ENTPD2
Identifiers
Aliases	ENTPD2, CD39L1, NTPDase-2, ectonucleoside triphosphate diphosphohydrolase 2
External IDs	OMIM: 602012; MGI: 1096863; HomoloGene: 20333; GeneCards: ENTPD2; OMA:ENTPD2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,054,061 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,291,333 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; tibial nerve; ; trigeminal ganglion; ; mucosa of transverse colon; ; right uterine tube; ; Amygdala; ; ventral tegmental area; ; skin of abdomen; ; Hypothalamus; ; sural nerve;
	Top expressed in
	seminal vesicula; ; sciatic nerve; ; ankle; ; tunica adventitia of aorta; ; lip; ; skin of external ear; ; carotid body; ; white adipose tissue; ; aortic valve; ; extraocular muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; nucleoside-diphosphatase activity; hydrolase activity; ATP binding; nucleoside-triphosphatase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; extracellular exosome; plasma membrane; basement membrane;
Biological process	G protein-coupled receptor signaling pathway; purine ribonucleoside diphosphate catabolic process; platelet activation; nucleobase-containing small molecule catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	954
	12496
	ENSG00000054179
	ENSMUSG00000015085
	Q9Y5L3
	O55026
	NM_001246; NM_203468
	NM_009849
	NP_001237; NP_982293
	NP_033979
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 2 is an enzyme that in humans is encoded by the ENTPD2 gene.

The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants.

It has been shown, by scientists from the University of Warwick, that E-NTPDase2 stimulates the growth of the eye: by testing the enzyme on tadpoles, the tadpoles were found to develop extra eyes on their body.