ENTPD3

ENTPD3
Identifiers
Aliases	ENTPD3, CD39L3, HB6, NTPDase-3, ectonucleoside triphosphate diphosphohydrolase 3
External IDs	OMIM: 603161; MGI: 1321386; HomoloGene: 68171; GeneCards: ENTPD3; OMA:ENTPD3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	40,428,744 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	120,397,393 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; periodontal fiber; ; middle temporal gyrus; ; parotid gland; ; putamen; ; nasal epithelium; ; tibia; ; caudate nucleus; ; minor salivary glands; ; decidua;
	Top expressed in
	molar; ; islet of Langerhans; ; vestibular membrane of cochlear duct; ; facial skeleton; ; transitional epithelium of urinary bladder; ; body of femur; ; lesser wing of sphenoid bone; ; membranous bone; ; Dermatocranium; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; hydrolase activity; ATP binding; nucleoside-diphosphatase activity; nucleoside-triphosphatase activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	nucleoside triphosphate catabolic process; nucleoside diphosphate catabolic process; nucleobase-containing small molecule catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	956
	215446
	ENSG00000168032
	ENSMUSG00000041608
	O75355
	Q8BFW6
	NM_001248; NM_001291960; NM_001291961
	NM_178676
	NP_001239; NP_001278889; NP_001278890
	NP_848791
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 3 is an enzyme that in humans is encoded by the ENTPD3 gene.

ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases.