ENTPD5

ENTPD5
Identifiers
Aliases	ENTPD5, CD39L4, NTPDase-5, PCPH, ectonucleoside triphosphate diphosphohydrolase 5, ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
External IDs	OMIM: 603162; MGI: 1321385; HomoloGene: 37457; GeneCards: ENTPD5; OMA:ENTPD5 - orthologs
EC number	3.6.1.42
Gene location (Human)
Chr.	Chromosome 14 (human)
End	74,019,399 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	84,455,803 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; rectum; ; jejunal mucosa; ; duodenum; ; liver; ; mucosa of transverse colon; ; right lobe of liver; ; human kidney; ; epithelium of colon; ; mucosa of ileum;
	Top expressed in
	proximal tubule; ; right kidney; ; human kidney; ; left lobe of liver; ; transitional epithelium of urinary bladder; ; olfactory epithelium; ; esophagus; ; right ventricle; ; jejunum; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	guanosine-diphosphatase activity; uridine-diphosphatase activity; protein binding; hydrolase activity; nucleoside-diphosphatase activity;
Cellular component	endoplasmic reticulum; extracellular region;
Biological process	'de novo' posttranslational protein folding; ATP metabolic process; protein glycosylation; protein N-linked glycosylation; cell population proliferation; positive regulation of glycolytic process; regulation of phosphatidylinositol 3-kinase signaling; nucleobase-containing small molecule catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	957
	12499
	ENSG00000187097
	ENSMUSG00000021236
	O75356
	Q9WUZ9
NM_001249; NM_001321984; NM_001321985; NM_001321986; NM_001321987;
	NM_001321988; NM_001330189; NM_001382256; NM_001382257; NM_001382258; NM_001382259; NM_001382260; NM_001382262; NM_001382263
	NM_001026214; NM_001286049; NM_001286058; NM_007647
NP_001240; NP_001308913; NP_001308914; NP_001308915; NP_001308916;
	NP_001308917; NP_001317118; NP_001369185; NP_001369186; NP_001369187; NP_001369188; NP_001369189; NP_001369191; NP_001369192
	NP_001021385; NP_001272978; NP_001272987; NP_031673
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleoside triphosphate diphosphohydrolase 5 is an enzyme that in humans is encoded by the ENTPD5 gene.

ENTPD5 is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.