Eomesodermin

EOMES
Identifiers
Aliases	EOMES, TBR2, Eomesodermin
External IDs	OMIM: 604615; MGI: 1201683; HomoloGene: 3971; GeneCards: EOMES; OMA:EOMES - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	27,722,711 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	118,315,200 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; granulocyte; ; cerebellar vermis; ; cerebellar hemisphere; ; testicle; ; right hemisphere of cerebellum; ; lymph node; ; blood; ; spleen;
	Top expressed in
	ventricular zone; ; olfactory bulb; ; epiblast; ; blastocyst; ; blastocyst; ; embryo; ; cerebellar vermis; ; mesoderm; ; blood; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; intracellular anatomical structure;
Biological process	stem cell population maintenance; regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of neurogenesis; gastrulation; trophectodermal cell differentiation; skeletal muscle cell differentiation; adaptive immune response; multicellular organism development; cell differentiation; blastocyst development; regulation of transcription, DNA-templated; cerebral cortex neuron differentiation; regulation of neuron differentiation; CD8-positive, alpha-beta T cell differentiation involved in immune response; transcription, DNA-templated; olfactory bulb development; endodermal cell fate specification; cerebral cortex regionalization; cardioblast differentiation; immune system process; positive regulation of cell differentiation; positive regulation of transcription by RNA polymerase II; brain development; regulation of gene expression; mesoderm formation; negative regulation of transcription by RNA polymerase II; mesodermal to mesenchymal transition involved in gastrulation; endoderm formation; cell differentiation involved in embryonic placenta development; negative regulation of DNA-binding transcription factor activity; neurogenesis; neuron differentiation; endoderm development; anatomical structure morphogenesis; mesendoderm development;
	Sources:Amigo / QuickGO
Orthologs
	8320
	13813
	ENSG00000163508
	ENSMUSG00000032446
	O95936
	O54839
	NM_001278182; NM_001278183; NM_005442
	NM_001164789; NM_010136
	NP_001265111; NP_001265112; NP_005433
	NP_001158261; NP_034266
	Wikidata
View/Edit Human	View/Edit Mouse

Eomesodermin also known as T-box brain protein 2 (Tbr2) is a protein that in humans is encoded by the EOMES gene.

The Eomesodermin/Tbr2 gene, EOMES, encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors, which control gene expression, involved in the regulation of developmental processes. Eomesodermin/Tbr2 itself controls regulation of radial glia, as well as other related cells. Eomesodermin/Tbr2 has also been found to have a role in immune response, and there exists some loose evidence for its connections in other systems.