EPH receptor A1

EPHA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K1K, 2K1L, 3HIL, 3KKA
Identifiers
Aliases	EPHA1, Epha1, 5730453L17Rik, AL033318, Eph, Esk, EPHT, EPHT1, EPH receptor A1, EPH
External IDs	OMIM: 179610; MGI: 107381; HomoloGene: 3835; GeneCards: EPHA1; OMA:EPHA1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	143,408,856 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	42,350,202 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; right uterine tube; ; right lobe of liver; ; minor salivary glands; ; vagina; ; left lobe of thyroid gland; ; ectocervix; ; mucosa of transverse colon; ; right lung;
	Top expressed in
	lip; ; tail of embryo; ; esophagus; ; embryo; ; epiblast; ; female urethra; ; right kidney; ; ascending aorta; ; male urethra; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; transmembrane-ephrin receptor activity; kinase activity; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; protein kinase binding; ephrin receptor activity; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; cytoplasm; neuron projection; receptor complex;
Biological process	somatic stem cell population maintenance; negative regulation of protein kinase activity; activation of GTPase activity; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell-matrix adhesion; positive regulation of cell migration; regulation of GTPase activity; positive regulation of angiogenesis; protein phosphorylation; cell surface receptor signaling pathway; negative regulation of cell migration; cell adhesion; angiogenesis; positive regulation of cell population proliferation; protein autophosphorylation; peptidyl-tyrosine phosphorylation; substrate adhesion-dependent cell spreading; positive regulation of stress fiber assembly; ephrin receptor signaling pathway; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	2041
	13835
	ENSG00000146904; ENSG00000284816
	ENSMUSG00000029859
	P21709
	Q60750
	NM_005232
	NM_023580
	NP_005223
	NP_076069
	Wikidata
View/Edit Human	View/Edit Mouse

EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene.

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.