EPH receptor A5

EPHA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2R2P, 4ET7
Identifiers
Aliases	EPHA5, CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4, EPH receptor A5
External IDs	OMIM: 600004; MGI: 99654; HomoloGene: 55824; GeneCards: EPHA5; OMA:EPHA5 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	65,670,495 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	84,565,241 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; sperm; ; prefrontal cortex; ; middle temporal gyrus; ; testicle; ; entorhinal cortex; ; dorsolateral prefrontal cortex; ; primary visual cortex; ; frontal pole;
	Top expressed in
	ganglionic eminence; ; ventral tegmental area; ; ventricular zone; ; Region I of hippocampus proper; ; substantia nigra; ; barrel cortex; ; olfactory bulb; ; piriform cortex; ; Amygdala; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; GPI-linked ephrin receptor activity; transmembrane-ephrin receptor activity; kinase activity; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; ephrin receptor activity; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; rough endoplasmic reticulum; cell projection; membrane; plasma membrane; integral component of plasma membrane; axon; soma; dendrite; perinuclear region of cytoplasm; external side of plasma membrane; cytoplasm; neuron projection; receptor complex;
Biological process	regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of actin cytoskeleton organization; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of GTPase activity; neuron development; nervous system development; protein phosphorylation; positive regulation of CREB transcription factor activity; peptidyl-tyrosine phosphorylation; hippocampus development; cAMP-mediated signaling; axon guidance; ephrin receptor signaling pathway; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	2044
	13839
	ENSG00000145242
	ENSMUSG00000029245
	P54756
	Q60629
NM_001281765; NM_001281766; NM_001281767; NM_004439; NM_182472;
	NM_001318761
	NM_007937
NP_001268694; NP_001268695; NP_001268696; NP_001305690; NP_004430;
	NP_872272
NP_031963; NP_001389678; NP_001389679; NP_001389680; NP_001389681;
	NP_001389682; NP_001389683; NP_001389684; NP_001389685; NP_001389686; NP_001389687; NP_001389688; NP_001389689; NP_001389690
	Wikidata
View/Edit Human	View/Edit Mouse

EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene.

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.