EPHA6

EPHA6
Identifiers
Aliases	EPHA6, EHK-2, EHK2, EK12, EPA6, HEK12, PRO57066, EPH receptor A6
External IDs	OMIM: 600066; MGI: 108034; HomoloGene: 56396; GeneCards: EPHA6; OMA:EPHA6 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	97,761,532 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	60,425,894 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; sperm; ; testicle; ; gonad; ; muscle layer of sigmoid colon; ; stromal cell of endometrium; ; Achilles tendon; ; prefrontal cortex; ; left ovary;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; lumbar spinal ganglion; ; Region I of hippocampus proper; ; hippocampus proper; ; primary visual cortex; ; superior frontal gyrus; ; zygote; ; CA3 field; ; tongue; ; cartilage of the septum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; ephrin receptor activity; molecular function; receptor tyrosine kinase; transmembrane signaling receptor activity; transmembrane-ephrin receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; nucleoplasm; cellular component; cytoplasm; neuron projection; receptor complex;
Biological process	phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; protein phosphorylation; peptidyl-tyrosine phosphorylation; ephrin receptor signaling pathway; biological process; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	285220
	13840
	ENSG00000080224
	ENSMUSG00000055540
	Q9UF33
	Q62413
	NM_001080448; NM_001278300; NM_001278301; NM_173655
	NM_007938
	NP_001073917; NP_001265229; NP_001265230; NP_775926
	NP_031964
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene.

EphA6 may serve an important role in breast carcinogenesis and may pose as a novel prognostic indicator and therapeutic target for breast cancer, particularly in patients with steroid receptor negative expression and HER‑2 overexpression