EPHA8

EPHA8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UCV, 1X5L, 3KUL
Identifiers
Aliases	EPHA8, EEK, EK3, HEK3, EPH receptor A8
External IDs	OMIM: 176945; MGI: 109378; HomoloGene: 22436; GeneCards: EPHA8; OMA:EPHA8 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	22,603,595 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	136,956,816 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; gonad; ; spleen; ; Hypothalamus; ; secondary oocyte; ; Mesencephalon; ; substantia nigra; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	neural layer of retina; ; cerebellar cortex; ; Ileal epithelium; ; perirhinal cortex; ; visual cortex; ; superior frontal gyrus; ; lacrimal groove; ; primary visual cortex; ; entorhinal cortex; ; lens;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; ephrin receptor activity; GPI-linked ephrin receptor activity; receptor tyrosine kinase; transmembrane signaling receptor activity; transmembrane-ephrin receptor activity;
Cellular component	integral component of membrane; endosome; cell projection; early endosome membrane; membrane; integral component of plasma membrane; plasma membrane; neuron projection; cytoplasm; receptor complex;
Biological process	phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; nervous system development; multicellular organism development; protein phosphorylation; cell adhesion; peptidyl-tyrosine phosphorylation; substrate-dependent cell migration; protein autophosphorylation; axon guidance; neuron projection development; regulation of cell adhesion; regulation of cell adhesion mediated by integrin; neuron remodeling; positive regulation of phosphatidylinositol 3-kinase activity; ephrin receptor signaling pathway; positive regulation of MAPK cascade; cellular response to follicle-stimulating hormone stimulus; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	2046
	13842
	ENSG00000070886
	ENSMUSG00000028661
	P29322
	O09127
	NM_001006943; NM_020526
	NM_007939
	NP_001006944; NP_065387
	NP_031965
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene.