EPH receptor B4

EPHB4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BBA, 2E7H, 2QKQ, 2VWU, 2VWV, 2VWW, 2VWX, 2VWY, 2VWZ, 2VX0, 2VX1, 2X9F, 2XVD, 2YN8, 3ZEW, 4AW5, 4BB4, 2HLE
Identifiers
Aliases	EPHB4, Ephb4, AI042935, Htk, MDK2, Myk1, Tyro11, EPH receptor B4, HTK, MYK1, TYRO11, HFASD, CMAVM2, LMPHM7
External IDs	OMIM: 600011; MGI: 104757; HomoloGene: 20939; GeneCards: EPHB4; OMA:EPHB4 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,827,523 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,376,931 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; beta cell; ; body of uterus; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; right lung; ; ectocervix; ; canal of the cervix;
	Top expressed in
	tail of embryo; ; genital tubercle; ; otic vesicle; ; saccule; ; atrium; ; yolk sac; ; left ventricle; ; aortic valve; ; lip; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; ephrin receptor activity; transmembrane-ephrin receptor activity;
Cellular component	integral component of membrane; cytosol; membrane; plasma membrane; integral component of plasma membrane; extracellular region; extracellular exosome; neuron projection; receptor complex;
Biological process	phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; heart morphogenesis; cell migration involved in sprouting angiogenesis; multicellular organism development; protein phosphorylation; cell adhesion; angiogenesis; protein autophosphorylation; peptidyl-tyrosine phosphorylation; ephrin receptor signaling pathway; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	2050
	13846
	ENSG00000196411
	ENSMUSG00000029710
	P54760
	P54761
	NM_004444
	NM_001159571; NM_010144
	NP_004435
	NP_001153043; NP_034274
	Wikidata
View/Edit Human	View/Edit Mouse

Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene.

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.