Epoxide hydrolase 2

EPHX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1S8O, 1VJ5, 1ZD2, 1ZD3, 1ZD4, 1ZD5, 3ANS, 3ANT, 3I1Y, 3I28, 3KOO, 3OTQ, 3PDC, 3WK4, 3WK5, 3WK6, 3WK7, 3WK8, 3WK9, 3WKA, 3WKB, 3WKC, 3WKD, 3WKE, 4C4X, 4C4Y, 4C4Z, 4HAI, 4J03, 4JNC, 4OCZ, 4OD0, 4X6X, 4X6Y, 4Y2J, 4Y2P, 4Y2Q, 4Y2R, 4Y2S, 4Y2T, 4Y2U, 4Y2V, 4Y2X, 4Y2Y, 5AHX, 5AI0, 5AI4, 5AI5, 5AI6, 5AI8, 5AI9, 5AIA, 5AIB, 5AIC, 5AK3, 5AK4, 5AK5, 5AK6, 5AKE, 5AKG, 5AKH, 5AKI, 5AKJ, 5AKK, 5AKL, 5AKX, 5AKY, 5AKZ, 5ALD, 5ALE, 5ALF, 5ALG, 5ALH, 5ALI, 5ALJ, 5ALK, 5ALL, 5ALM, 5ALN, 5ALO, 5ALP, 5ALQ, 5ALR, 5ALS, 5ALT, 5ALU, 5ALV, 5ALW, 5ALX, 5ALY, 5ALZ, 5AM0, 5AM1, 5AM2, 5AM3, 5AM4, 5AM5, 5FP0
Identifiers
Aliases	EPHX2, CEH, SEH, Epoxide hydrolase 2, ABHD20
External IDs	OMIM: 132811; MGI: 99500; HomoloGene: 37558; GeneCards: EPHX2; OMA:EPHX2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	27,545,564 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	66,361,949 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; mucosa of transverse colon; ; right adrenal gland; ; right adrenal cortex; ; rectum; ; left adrenal cortex; ; body of pancreas; ; human kidney; ; right uterine tube; ; jejunal mucosa;
	Top expressed in
	right kidney; ; left lobe of liver; ; brown adipose tissue; ; duodenum; ; myocardium of ventricle; ; cumulus cell; ; cardiac muscles; ; tunica adventitia of aorta; ; right ventricle; ; human kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity; phosphatase activity; metal ion binding; catalytic activity; lipid phosphatase activity; signaling receptor binding; hydrolase activity; magnesium ion binding; toxic substance binding; protein homodimerization activity; epoxide hydrolase activity;
Cellular component	extracellular exosome; peroxisome; cytosol; cytoplasm; peroxisomal matrix;
Biological process	phospholipid dephosphorylation; lipid metabolism; epoxygenase P450 pathway; cellular calcium ion homeostasis; reactive oxygen species metabolic process; regulation of blood pressure; regulation of cholesterol metabolic process; stilbene catabolic process; xenobiotic metabolic process; metabolism; aromatic compound catabolic process; inflammatory response; dephosphorylation; positive regulation of gene expression; response to toxic substance; cholesterol homeostasis; epoxide metabolic process; protein targeting to peroxisome; long-chain fatty acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2053
	13850
	ENSG00000120915
	ENSMUSG00000022040
	P34913
	P34914
	NM_001979; NM_001256482; NM_001256483; NM_001256484
	NM_001271402; NM_001271403; NM_001271421; NM_007940
	NP_001243411; NP_001243412; NP_001243413; NP_001970
	NP_001258331; NP_001258332; NP_001258350; NP_031966
	Wikidata
View/Edit Human	View/Edit Mouse

Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that in humans is encoded by the EPHX2 gene. sEH is a member of the epoxide hydrolase family. This enzyme, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding diols. A different region of this protein also has lipid-phosphate phosphatase activity. Mutations in the EPHX2 gene have been associated with familial hypercholesterolemia.