EPN1

EPN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1INZ
Identifiers
Aliases	EPN1, epsin 1
External IDs	OMIM: 607262; MGI: 1333763; HomoloGene: 32172; GeneCards: EPN1; OMA:EPN1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,709,858 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	5,098,178 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; body of stomach; ; mucosa of transverse colon; ; right frontal lobe; ; right auricle of heart; ; anterior cingulate cortex; ; left testis; ; muscle of thigh; ; right testis; ; body of pancreas;
	Top expressed in
	Ileal epithelium; ; perirhinal cortex; ; CA3 field; ; entorhinal cortex; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; lactiferous gland; ; choroid plexus of fourth ventricle; ; ankle joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; lipid binding;
Cellular component	cytoplasm; plasma membrane; clathrin-coated pit; membrane; nucleus; cytosol;
Biological process	Notch signaling pathway; female pregnancy; negative regulation of epidermal growth factor receptor signaling pathway; in utero embryonic development; endocytosis; embryonic organ development; membrane organization; negative regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	29924
	13854
	ENSG00000063245
	ENSMUSG00000035203
	Q9Y6I3
	Q80VP1
	NM_001130071; NM_001130072; NM_013333; NM_001321263
	NM_001252454; NM_010147
	NP_001123543; NP_001123544; NP_001308192; NP_037465
	NP_001239383; NP_034277; NP_001359429
	Wikidata
View/Edit Human	View/Edit Mouse

Epsin-1 is a protein that in humans is encoded by the EPN1 gene.

EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles.[supplied by OMIM]