EPN2

EPN2
Identifiers
Aliases	EPN2, EHB21, epsin 2
External IDs	OMIM: 607263; MGI: 1333766; HomoloGene: 40710; GeneCards: EPN2; OMA:EPN2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	19,336,715 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	61,579,687 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; corpus callosum; ; Amygdala; ; C1 segment; ; skin of abdomen; ; skin of leg; ; sural nerve; ; ectocervix; ; prefrontal cortex; ; cingulate gyrus;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; spermatocyte; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; lipid binding; cadherin binding;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; cytoplasmic vesicle; clathrin-coated vesicle; clathrin coat of endocytic vesicle; cytosol;
Biological process	endocytosis; membrane organization; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of Notch signaling pathway; negative regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	22905
	13855
	ENSG00000072134
	ENSMUSG00000001036
	O95208
	Q8CHU3
	NM_148921; NM_001102664; NM_014964
NM_001252188; NM_001252189; NM_010148; NM_001362585; NM_001362586;
	NM_001362587
	NP_001096134; NP_055779; NP_683723
NP_001239117; NP_001239118; NP_034278; NP_001349514; NP_001349515;
	NP_001349516
	Wikidata
View/Edit Human	View/Edit Mouse

Epsin-2 is a protein that in humans is encoded by the EPN2 gene.

This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in two transcript variants encoding different isoforms.