EPPTB

EPPTB
Clinical data
Other names	Ro 5212773; Ro-5212773; Ro5212773; RO-5212773; RO5212773
Drug class	Trace amine-associated receptor 1 (TAAR1) antagonist or inverse agonist
Identifiers
	IUPAC name N-(3-ethoxyphenyl)-4-pyrrolidin-1-yl-3-trifluoromethylbenzamide;
CAS Number	1110781-88-8;
PubChem CID	25175634;
IUPHAR/BPS	5457;
ChemSpider	26387935;
ChEMBL	ChEMBL1669669;
CompTox Dashboard (EPA)	DTXSID501030324 ;
Chemical and physical data
Formula	C20H21F3N2O2
Molar mass	378.395 g·mol−1
3D model (JSmol)	Interactive image; Interactive image;
	SMILES CCOc2cc(ccc2)NC(=O)c(cc1C(F)(F)F)ccc1N3CCCC3; ; CCOc1cccc(c1)NC(=O)c2ccc(c(c2)C(F)(F)F)N3CCCC3;
	InChI InChI=1S/C20H21F3N2O2/c1-2-27-16-7-5-6-15(13-16)24-19(26)14-8-9-18(25-10-3-4-11-25)17(12-14)20(21,22)23/h5-9,12-13H,2-4,10-11H2,1H3,(H,24,26); Key:KLFVWQCQUXXLOU-UHFFFAOYSA-N;

EPPTB, also known as RO5212773 or RO-5212773, is a drug developed by Hoffmann-La Roche which acts as a potent and selective antagonist or inverse agonist of the trace amine-associated receptor 1 (TAAR1). The drug was the first selective antagonist developed for the TAAR1. It is a potent agonist of the mouse and rat TAAR1, but is dramatically less potent as an agonist of the human TAAR1. EPPTB has been used in scientific research to demonstrate an important role for TAAR1 in regulation of dopaminergic signaling in the limbic system.