EPS8

EPS8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E8M
Identifiers
Aliases	EPS8, DFNB102, epidermal growth factor receptor pathway substrate 8
External IDs	OMIM: 600206; MGI: 104684; HomoloGene: 3272; GeneCards: EPS8; OMA:EPS8 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	15,882,329 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	137,631,874 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of sigmoid colon; ; Achilles tendon; ; cartilage tissue; ; corpus epididymis; ; pericardium; ; tail of epididymis; ; popliteal artery; ; tibial arteries; ; synovial joint;
	Top expressed in
	secondary oocyte; ; left colon; ; zygote; ; seminal vesicula; ; migratory enteric neural crest cell; ; primary oocyte; ; ileum; ; conjunctival fornix; ; right kidney; ; parotid gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling adaptor activity; protein binding; actin binding;
Cellular component	cytoplasm; vesicle; cell projection; membrane; postsynaptic density; growth cone; plasma membrane; synapse; NMDA selective glutamate receptor complex; stereocilium; ruffle membrane; cell junction; cell cortex; brush border; neuron projection; extracellular exosome; stereocilium bundle; stereocilium tip; glutamatergic synapse;
Biological process	actin cytoskeleton reorganization; actin polymerization-dependent cell motility; epidermal growth factor receptor signaling pathway; regulation of actin filament length; adult locomotory behavior; barbed-end actin filament capping; exit from mitosis; actin filament bundle assembly; dendritic cell migration; actin crosslink formation; regulation of cell shape; behavioral response to ethanol; cell population proliferation; Rac protein signal transduction; signal transduction; positive regulation of signal transduction; cellular response to leukemia inhibitory factor; Rho protein signal transduction; regulation of Rho protein signal transduction; regulation of postsynaptic membrane neurotransmitter receptor levels; positive regulation of ruffle assembly;
	Sources:Amigo / QuickGO
Orthologs
	2059
	13860
	ENSG00000151491
	ENSMUSG00000015766
	Q12929
	Q08509
	NM_004447
	NM_001271587; NM_001271588; NM_001271589; NM_001271595; NM_007945
	NP_004438
	NP_001258516; NP_001258517; NP_001258518; NP_001258524; NP_031971
	Wikidata
View/Edit Human	View/Edit Mouse

Epidermal growth factor receptor kinase substrate 8 is an enzyme that in humans is encoded by the EPS8 gene.