ERAP2

ERAP2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3SE6, 4E36, 4JBS, 5CU5, 5AB2, 5AB0
Identifiers
Aliases	ERAP2, L-RAP, LRAP, endoplasmic reticulum aminopeptidase 2
External IDs	OMIM: 609497; HomoloGene: 75183; GeneCards: ERAP2; OMA:ERAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	96,919,703 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; granulocyte; ; lymph node; ; superficial temporal artery; ; visceral pleura; ; epithelium of nasopharynx; ; monocyte; ; epithelium of colon; ; appendix; ; Achilles tendon;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	aminopeptidase activity; metallopeptidase activity; peptidase activity; hydrolase activity; zinc ion binding; metal ion binding; peptide binding; metalloaminopeptidase activity; endopeptidase activity;
Cellular component	integral component of membrane; endoplasmic reticulum lumen; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; plasma membrane; cytoplasm;
Biological process	immune system process; adaptive immune response; proteolysis; regulation of blood pressure; antigen processing and presentation of peptide antigen via MHC class I; peptide catabolic process; antigen processing and presentation of endogenous peptide antigen via MHC class I; signal transduction; cell-cell signaling;
	Sources:Amigo / QuickGO
Orthologs
	64167
	n/a
	ENSG00000164308
	n/a
	Q6P179
	n/a
	NM_001130140; NM_022350; NM_001329229; NM_001329233
	n/a
	NP_001123612; NP_001316158; NP_001316162; NP_071745
	n/a
	Wikidata
View/Edit Human

Endoplasmic reticulum aminopeptidase 2 (ERAP2) is a protein that in humans is encoded by the ERAP2 gene. ERAP2 is part of the M1 aminopeptidase family. It is expressed along with ERAP1 in the endoplasmic reticulum (ER). In the ER, both enzymes help process and present antigens by trimming the ends of precursor peptides. This creates the optimal pieces for display by Major Histocompatibility Complex (MHC) class I molecules.