ERBB4

ERBB4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AHX, 2L2T, 2LCX, 2R4B, 3BBT, 3BBW, 3BCE, 3U2P, 3U7U, 3U9U
Identifiers
Aliases	ERBB4, ALS19, HER4, p180erbB4, erb-b2 receptor tyrosine kinase 4
External IDs	OMIM: 600543; MGI: 104771; HomoloGene: 21084; GeneCards: ERBB4; OMA:ERBB4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	212,538,841 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	69,147,218 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; secondary oocyte; ; optic nerve; ; middle temporal gyrus; ; buccal mucosa cell; ; Brodmann area 23; ; entorhinal cortex; ; Brodmann area 46; ; orbitofrontal cortex; ; right uterine tube;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; interventricular septum; ; visual cortex; ; primary visual cortex; ; Cardiac muscle tissue of myocardium; ; cardiac muscle tissue of left ventricle; ; corneal stroma; ; plantaris muscle; ; gray matter layer of cerebellum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein homodimerization activity; epidermal growth factor receptor binding; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; cytosol; membrane; receptor complex; plasma membrane; nucleoplasm; extracellular region; mitochondrial matrix; basolateral plasma membrane; mitochondrion; nucleus; postsynaptic membrane; glutamatergic synapse; GABA-ergic synapse; integral component of presynaptic membrane; integral component of postsynaptic density membrane; cytoplasm; integral component of plasma membrane; basal plasma membrane;
Biological process	mitochondrial fragmentation involved in apoptotic process; negative regulation of neuron migration; cell fate commitment; positive regulation of protein phosphorylation; regulation of cell migration; regulation of transcription, DNA-templated; olfactory bulb interneuron differentiation; embryonic pattern specification; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; central nervous system morphogenesis; mammary gland alveolus development; transcription, DNA-templated; nervous system development; mammary gland epithelial cell differentiation; MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of transcription, DNA-templated; multicellular organism development; heart development; protein phosphorylation; positive regulation of cardiac muscle cell proliferation; neural crest cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of protein localization to cell surface; protein autophosphorylation; cardiac muscle tissue regeneration; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; lactation; cell population proliferation; cell migration; signal transduction; negative regulation of cell population proliferation; apoptotic process; ERBB2 signaling pathway; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine autophosphorylation; positive regulation of cell population proliferation; positive regulation of apoptotic process; regulation of cell motility; negative regulation of apoptotic process; cellular response to epidermal growth factor stimulus; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of protein kinase B signaling; positive regulation of receptor signaling pathway via JAK-STAT; synapse assembly; negative regulation of signal transduction; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	2066
	13869
	ENSG00000178568
	ENSMUSG00000062209
	Q15303
	Q61527
	NM_001042599; NM_005235
	NM_010154
	NP_001036064; NP_005226
	NP_034284
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.