ERCC5

ERCC5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5EKF, 5EKG
Identifiers
Aliases	ERCC5, COFS3, ERCM2, UVDR, XPG, XPGC, ERCC5-201, excision repair cross-complementation group 5, ERCC excision repair 5, endonuclease
External IDs	OMIM: 133530; MGI: 103582; HomoloGene: 133551; GeneCards: ERCC5; OMA:ERCC5 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	102,875,995 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	44,220,420 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; Achilles tendon; ; body of pancreas; ; skin of leg; ; skin of abdomen; ; right lobe of liver; ; anterior pituitary; ; right lung; ; mucosa of transverse colon; ; tibial nerve;
	Top expressed in
	Rostral migratory stream; ; genital tubercle; ; tail of embryo; ; stroma of bone marrow; ; ganglionic eminence; ; ventricular zone; ; neural layer of retina; ; corneal stroma; ; ciliary body; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein homodimerization activity; hydrolase activity, acting on ester bonds; protein N-terminus binding; bubble DNA binding; metal ion binding; single-stranded DNA binding; protein binding; catalytic activity; nuclease activity; endonuclease activity; double-stranded DNA binding; endodeoxyribonuclease activity; hydrolase activity; RNA polymerase II complex binding; protein-containing complex binding;
Cellular component	RNA polymerase II, holoenzyme; transcription factor TFIIH holo complex; DNA replication factor A complex; nucleus; nucleoplasm; nucleotide-excision repair complex;
Biological process	negative regulation of apoptotic process; cellular response to DNA damage stimulus; UV protection; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; response to UV; response to UV-C; nucleotide-excision repair; nucleotide-excision repair, preincision complex stabilization; DNA repair; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, DNA incision, 3'-to lesion;
	Sources:Amigo / QuickGO
Orthologs
	2073
	22592
	ENSG00000134899
	ENSMUSG00000026048
	P28715
	P35689
	NM_000123
	NM_011729
	NP_000114
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

DNA repair protein complementing XP-G cells is a protein that in humans is encoded by the ERCC5 gene.