ERH (gene)

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Enhancer of rudimentary
Enhancer of rudimentary
	crystal structure of enhancer of rudimentary homologue (erh)
Identifiers
Symbol	ER
Pfam	PF01133
InterPro	IPR000781
PROSITE	PDOC00732
SCOP2	1j24 / SCOPe / SUPFAM
TCDB	3.A.16
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ERH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W9G, 2NML
Identifiers
Aliases	ERH, DROER, enhancer of rudimentary homolog (Drosophila), mRNA splicing and mitosis factor, ERH mRNA splicing and mitosis factor
External IDs	OMIM: 601191; MGI: 108089; HomoloGene: 3274; GeneCards: ERH; OMA:ERH - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	69,398,299 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	80,691,115 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; embryo; ; ganglionic eminence; ; ventricular zone; ; Epithelium of choroid plexus; ; lactiferous duct; ; nasal epithelium; ; renal medulla; ; caput epididymis; ; islet of Langerhans;
	Top expressed in
	embryo; ; yolk sac; ; ventricular zone; ; embryo; ; tail of embryo; ; morula; ; blastocyst; ; zygote; ; genital tubercle; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyl-CpG binding; protein binding; RNA binding;
Cellular component	methylosome; midbody;
Biological process	pyrimidine nucleoside metabolic process; cell cycle; nucleobase-containing compound metabolic process; pyrimidine nucleotide biosynthetic process; positive regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2079
	13877
	ENSG00000100632
	ENSMUSG00000021131
	P84090
	P84089
	NM_004450
	NM_007951; NM_001347409
	NP_004441
	NP_001334338; NP_031977
	Wikidata
View/Edit Human	View/Edit Mouse

In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ERH gene.

The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis.

From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms. It has been proposed that this protein plays a role in the cell cycle.