MAPK3

MAPK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZOQ, 4QTB
Identifiers
Aliases	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, mitogen-activated protein kinase 3
External IDs	OMIM: 601795; MGI: 1346859; HomoloGene: 55682; GeneCards: MAPK3; OMA:MAPK3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,123,506 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,364,991 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; mucosa of transverse colon; ; Amygdala; ; cingulate gyrus; ; anterior cingulate cortex; ; gastric mucosa; ; nucleus accumbens; ; ectocervix; ; rectum; ; C1 segment;
	Top expressed in
	granulocyte; ; dentate gyrus of hippocampal formation granule cell; ; yolk sac; ; pyloric antrum; ; lip; ; entorhinal cortex; ; large intestine; ; colon; ; epithelium of stomach; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatase binding; ATP binding; protein kinase activity; MAP kinase activity; transferase activity; phosphotyrosine residue binding; scaffold protein binding; protein binding; nucleotide binding; kinase activity; protein serine/threonine kinase activity; MAP kinase kinase activity; identical protein binding;
Cellular component	cytosol; nuclear envelope; focal adhesion; mitochondrion; cytoskeleton; nucleus; late endosome; Golgi apparatus; early endosome; pseudopodium; nucleoplasm; cytoplasm; plasma membrane; caveola; membrane; protein-containing complex;
Biological process	caveolin-mediated endocytosis; positive regulation of protein phosphorylation; positive regulation of telomere capping; response to exogenous dsRNA; cardiac neural crest cell development involved in heart development; positive regulation of xenophagy; positive regulation of translation; cellular response to DNA damage stimulus; platelet activation; Fc-epsilon receptor signaling pathway; protein phosphorylation; cellular response to mechanical stimulus; face development; positive regulation of histone modification; regulation of DNA-binding transcription factor activity; DNA damage induced protein phosphorylation; positive regulation of ERK1 and ERK2 cascade; animal organ morphogenesis; cell cycle; apoptotic process; Fc-gamma receptor signaling pathway involved in phagocytosis; thymus development; ERK1 and ERK2 cascade; negative regulation of apolipoprotein binding; transcription, DNA-templated; cartilage development; viral process; response to toxic substance; regulation of stress-activated MAPK cascade; phosphorylation; outer ear morphogenesis; BMP signaling pathway; response to lipopolysaccharide; thyroid gland development; response to epidermal growth factor; positive regulation of MAP kinase activity; positive regulation of telomerase activity; peptidyl-tyrosine autophosphorylation; sensory perception of pain; positive regulation of cyclase activity; trachea formation; lipopolysaccharide-mediated signaling pathway; intracellular signal transduction; lung morphogenesis; neural crest cell development; transcription initiation from RNA polymerase I promoter; regulation of early endosome to late endosome transport; positive regulation of telomere maintenance via telomerase; MAPK cascade; positive regulation of histone acetylation; axon guidance; interleukin-1-mediated signaling pathway; fibroblast growth factor receptor signaling pathway; peptidyl-serine phosphorylation; regulation of cellular response to heat; Bergmann glial cell differentiation; regulation of Golgi inheritance; arachidonic acid metabolic process; regulation of cytoskeleton organization; positive regulation of transcription by RNA polymerase II; regulation of phosphatidylinositol 3-kinase signaling; regulation of ossification; positive regulation of gene expression; positive regulation of macrophage chemotaxis; cellular response to amino acid starvation; cellular response to reactive oxygen species; stress-activated MAPK cascade; cellular response to cadmium ion; cellular response to dopamine; positive regulation of metallopeptidase activity; regulation of cellular pH; protein-containing complex assembly; cellular response to tumor necrosis factor; regulation of gene expression; cellular response to organic substance; ageing; decidualization;
	Sources:Amigo / QuickGO
Orthologs
	5595
	26417
	ENSG00000102882
	ENSMUSG00000063065
	P27361
	Q63844
	NM_001040056; NM_001109891; NM_002746
	NM_011952
	NP_001035145; NP_001103361; NP_002737
	NP_036082
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1, is an enzyme that in humans is encoded by the MAPK3 gene.