ERRFI1

ERRFI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RF9, 2RFD, 2RFE, 4I21, 4R3P, 4R3R, 4ZJV
Identifiers
Aliases	ERRFI1, GENE-33, MIG-6, MIG6, RALT, ERBB receptor feedback inhibitor 1
External IDs	OMIM: 608069; MGI: 1921405; HomoloGene: 10344; GeneCards: ERRFI1; OMA:ERRFI1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	8,026,309 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	150,953,349 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; vena cava; ; right lobe of liver; ; tibialis anterior muscle; ; gastric mucosa; ; tibial arteries; ; synovial joint; ; left ovary; ; cartilage tissue; ; ascending aorta;
	Top expressed in
	left lobe of liver; ; gastrula; ; decidua; ; gallbladder; ; human kidney; ; endothelial cell of lymphatic vessel; ; right lung lobe; ; left lung; ; left lung lobe; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activator activity; SH3 domain binding; kinase binding; protein binding; protein kinase binding; small GTPase binding;
Cellular component	membrane; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; nucleus; cytoplasm; cytosol;
Biological process	negative regulation of interleukin-1 beta production; negative regulation of epidermal growth factor receptor signaling pathway; skin morphogenesis; negative regulation of protein autophosphorylation; cellular response to platelet-derived growth factor stimulus; cellular response to dexamethasone stimulus; cellular response to epidermal growth factor stimulus; cellular hyperosmotic response; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of peptidyl-tyrosine phosphorylation; cellular response to insulin stimulus; negative regulation of ERK1 and ERK2 cascade; regulation of keratinocyte differentiation; lung alveolus development; lung vasculature development; lung epithelium development; regulation of type B pancreatic cell proliferation; negative regulation of collagen biosynthetic process; negative regulation of cardiac muscle hypertrophy in response to stress; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	54206
	74155
	ENSG00000116285
	ENSMUSG00000028967
	Q9UJM3
	Q99JZ7
	NM_018948
	NM_133753; NM_001356323
	NP_061821
	NP_598514; NP_001343252
	Wikidata
View/Edit Human	View/Edit Mouse

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.

MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).