Estrogen-related receptor alpha

ESRRA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XB7, 2PJL, 3D24, 3K6P
Identifiers
Aliases	ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1, estrogen related receptor alpha
External IDs	OMIM: 601998; MGI: 1346831; HomoloGene: 136738; GeneCards: ESRRA; OMA:ESRRA - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,316,743 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,899,208 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; mucosa of transverse colon; ; gastrocnemius muscle; ; muscle of thigh; ; right auricle of heart; ; left ventricle; ; right lobe of liver; ; pancreatic ductal cell; ; body of stomach; ; minor salivary glands;
	Top expressed in
	interventricular septum; ; choroid plexus of fourth ventricle; ; muscle of thigh; ; Rostral migratory stream; ; gallbladder; ; jejunum; ; duodenum; ; extensor digitorum longus muscle; ; digastric muscle; ; ileum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein domain specific binding; DNA-binding transcription factor activity; zinc ion binding; DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; steroid hormone receptor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; nuclear receptor activity; steroid binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	microtubule cytoskeleton; nucleoplasm; intercellular bridge; nucleus; fibrillar center; cytoplasm;
Biological process	response to estradiol; regulation of transcription, DNA-templated; positive regulation of cellular response to insulin stimulus; mitochondrion organization; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of transcription, DNA-templated; cartilage development; regulation of cell population proliferation; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of ossification; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; steroid hormone mediated signaling pathway; intracellular receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2101
	26379
	ENSG00000173153
	ENSMUSG00000024955
	P11474
	O08580
	NM_001282450; NM_001282451; NM_004451
	NM_007953
	NP_001269379; NP_001269380; NP_004442
	NP_031979
	Wikidata
View/Edit Human	View/Edit Mouse

Estrogen-related receptor alpha (ERRα), also known as NR3B1 (nuclear receptor subfamily 3, group B, member 1), is a nuclear receptor that in humans is encoded by the ESRRA (Estrogen Related Receptor Alpha) gene. ERRα was originally cloned by DNA sequence homology to the estrogen receptor alpha (ERα, NR3A1), but subsequent ligand binding and reporter-gene transfection experiments demonstrated that estrogens did not regulate ERRα. Currently, ERRα is considered an orphan nuclear receptor.