Eukaryotic translation termination factor 1

ETF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DT9, 2HST, 2KTU, 2KTV, 2LGT, 2LLX, 3E1Y, 3J5Y, 4D5N, 4D61, 2MQ6, 2MQ9, 3JAG, 3JAH, 3JAI, 5A8L
Identifiers
Aliases	ETF1, D5S1995, ERF, ERF1, RF1, SUP45L1, TB3-1, eukaryotic translation termination factor 1
External IDs	OMIM: 600285; MGI: 2385071; HomoloGene: 3475; GeneCards: ETF1; OMA:ETF1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	138,543,236 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	35,065,060 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; skin of thigh; ; mucosa of sigmoid colon; ; skin of abdomen; ; cartilage tissue; ; lower lobe of lung; ; smooth muscle tissue; ; gastrocnemius muscle; ; placenta; ; bone marrow;
	Top expressed in
	epiblast; ; primitive streak; ; somite; ; lens; ; mandibular prominence; ; tail of embryo; ; maxillary prominence; ; spermatid; ; endothelial cell of lymphatic vessel; ; lactiferous gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	ribosome binding; translation termination factor activity; protein binding; RNA binding; sequence-specific mRNA binding; translation release factor activity; translation release factor activity, codon specific;
Cellular component	cytoplasm; cytosol; nucleus; translation release factor complex;
Biological process	translational termination; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of translational termination; protein methylation; protein biosynthesis; cytoplasmic translational termination;
	Sources:Amigo / QuickGO
Orthologs
	2107
	225363
	ENSG00000120705
	ENSMUSG00000024360
	P62495
	Q8BWY3
NM_001256302; NM_001282185; NM_001291974; NM_001291975; NM_004730;
	NM_001364160
	NM_144866
NP_001243231; NP_001269114; NP_001278903; NP_001278904; NP_004721;
	NP_001351089
	NP_659115
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation termination factor 1 (eRF1), also referred to as TB3-1 or SUP45L1, is a protein that is encoded by the ERF1 gene. In Eukaryotes, eRF1 is an essential protein involved in stop codon recognition in translation, termination of translation, and nonsense mediated mRNA decay via the SURF complex.