ETFDH

ETFDH
Identifiers
Aliases	ETFDH, electron-transferring-flavoprotein dehydrogenase, ETFQO, MADD, electron transfer flavoprotein dehydrogenase
External IDs	OMIM: 231675; MGI: 106100; HomoloGene: 3275; GeneCards: ETFDH; OMA:ETFDH - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	158,710,742 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	79,536,807 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; left ventricle; ; muscle of thigh; ; right lobe of liver; ; jejunal mucosa; ; right auricle of heart; ; right ventricle; ; gastrocnemius muscle; ; right adrenal gland; ; right adrenal cortex;
	Top expressed in
	right ventricle; ; myocardium of ventricle; ; cardiac muscles; ; interventricular septum; ; cardiac muscle tissue of left ventricle; ; intercostal muscle; ; digastric muscle; ; soleus muscle; ; thoracic diaphragm; ; brown adipose tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	4 iron, 4 sulfur cluster binding; ubiquinone binding; quinone binding; flavin adenine dinucleotide binding; iron-sulfur cluster binding; metal ion binding; electron transfer activity; oxidoreductase activity; electron-transferring-flavoprotein dehydrogenase activity; oxidoreductase activity, acting on metal ions, flavin as acceptor;
Cellular component	membrane; integral component of mitochondrial inner membrane; mitochondrial matrix; mitochondrion; mitochondrial inner membrane; mitochondrial membranes; mitochondrial electron transfer flavoprotein complex;
Biological process	fatty acid beta-oxidation using acyl-CoA dehydrogenase; response to oxidative stress; electron transport chain; respiratory electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	2110
	66841
	ENSG00000171503
	ENSMUSG00000027809
	Q16134
	Q921G7
	NM_004453; NM_001281737; NM_001281738
	NM_025794
	NP_001268666; NP_001268667; NP_004444
	NP_080070
	Wikidata
View/Edit Human	View/Edit Mouse

Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial is an enzyme that in humans is encoded by the ETFDH gene. This gene encodes a component of the electron-transfer system in mitochondria and is essential for electron transfer from a number of mitochondrial flavin-containing dehydrogenases to the main respiratory chain.