ETV6

ETV6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JI7, 1LKY, 2DAO, 2QAR, 2QB0, 2QB1
Identifiers
Aliases	ETV6, TEL, TEL/ABL, THC5, ETS variant 6, ETS variant transcription factor 6
External IDs	OMIM: 600618; MGI: 109336; HomoloGene: 37560; GeneCards: ETV6; OMA:ETV6 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	11,895,377 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	134,247,121 bp
RNA expression pattern
	Top expressed in
	mucosa of paranasal sinus; ; parotid gland; ; lactiferous duct; ; olfactory zone of nasal mucosa; ; epithelium of nasopharynx; ; saphenous vein; ; monocyte; ; tibial arteries; ; minor salivary glands; ; tonsil;
	Top expressed in
	tail of embryo; ; genital tubercle; ; lacrimal gland; ; cumulus cell; ; vestibular membrane of cochlear duct; ; internal carotid artery; ; external carotid artery; ; conjunctival fornix; ; granulocyte; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein domain specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleolus; nucleus; cytosol;
Biological process	hematopoietic stem cell proliferation; cell differentiation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; vitellogenesis; mesenchymal cell apoptotic process; neurogenesis; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2120
	14011
	ENSG00000139083
	ENSMUSG00000030199
	P41212
	P97360
	NM_001987
	NM_007961; NM_001303102
	NP_001978
	NP_001290031; NP_031987
	Wikidata
View/Edit Human	View/Edit Mouse

ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is encoded by the ETV6 (previously known as TEL) gene. The ETV6 protein regulates the development and growth of diverse cell types, particularly those of hematological tissues. However, its gene, ETV6 frequently suffers various mutations that lead to an array of potentially lethal cancers, i.e., ETV6 is a clinically significant proto-oncogene in that it can fuse with other genes to drive the development and/or progression of certain cancers. However, ETV6 is also an anti-oncogene or tumor suppressor gene in that mutations in it that encode for a truncated and therefore inactive protein are also associated with certain types of cancers.