Exonuclease 1

EXO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QE9, 3QEA, 3QEB
Identifiers
Aliases	EXO1, HEX1, hExoI, exonuclease 1
External IDs	OMIM: 606063; MGI: 1349427; HomoloGene: 31352; GeneCards: EXO1; OMA:EXO1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	241,895,148 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	175,741,055 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; gonad; ; ganglionic eminence; ; testicle; ; trabecular bone; ; bone marrow; ; bone marrow cells; ; stromal cell of endometrium; ; secondary oocyte; ; mucosa of transverse colon;
	Top expressed in
	epiblast; ; primary oocyte; ; zygote; ; embryo; ; nasolacrimal duct; ; morula; ; secondary oocyte; ; embryo; ; spermatocyte; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	endonuclease activity; double-stranded DNA 5'-3' exodeoxyribonuclease activity; single-stranded DNA 5'-3' exodeoxyribonuclease activity; DNA binding; 5'-3' exonuclease activity; nuclease activity; RNA-DNA hybrid ribonuclease activity; protein binding; 5'-3' exodeoxyribonuclease activity; flap endonuclease activity; chromatin binding; exonuclease activity; hydrolase activity, acting on ester bonds; catalytic activity; hydrolase activity; metal ion binding; double-stranded DNA binding; 5'-flap endonuclease activity;
Cellular component	nucleus; nucleoplasm; nuclear body; plasma membrane;
Biological process	DNA recombination; immune system process; humoral immune response mediated by circulating immunoglobulin; DNA mismatch repair; cellular response to DNA damage stimulus; somatic hypermutation of immunoglobulin genes; meiosis; isotype switching; DNA repair; RNA phosphodiester bond hydrolysis, endonucleolytic; nucleic acid phosphodiester bond hydrolysis; DNA replication; t-circle formation; meiotic DNA double-strand break processing; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	9156
	26909
	ENSG00000174371
	ENSMUSG00000039748
	Q9UQ84; Q5T397
	Q9QZ11
	NM_003686; NM_006027; NM_130398; NM_001319224
	NM_012012
	NP_001306153; NP_003677; NP_006018; NP_569082
	NP_036142
	Wikidata
View/Edit Human	View/Edit Mouse

Exonuclease 1 is an enzyme that in humans is encoded by the EXO1 gene.

This gene encodes a protein with 5' to 3' exonuclease activity as well as RNase activity (endonuclease activity cleaving RNA on DNA/RNA hybrid). It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in DNA mismatch repair and homologous recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms.