EXOC1

EXOC1
Identifiers
Aliases	EXOC1, BM-102, SEC3, SEC3L1, SEC3P, exocyst complex component 1
External IDs	OMIM: 607879; MGI: 2445020; HomoloGene: 41241; GeneCards: EXOC1; OMA:EXOC1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	55,905,086 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	76,570,294 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; skin of thigh; ; skin of hip; ; oral cavity; ; Achilles tendon; ; mucosa of sigmoid colon; ; parietal pleura; ; visceral pleura; ; inferior olivary nucleus; ; germinal epithelium;
	Top expressed in
	neural layer of retina; ; zygote; ; secondary oocyte; ; granulocyte; ; tail of embryo; ; dentate gyrus of hippocampal formation granule cell; ; spermatocyte; ; ventricular zone; ; genital tubercle; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-4,5-bisphosphate binding; protein binding;
Cellular component	cytoplasmic side of apical plasma membrane; cytosol; plasma membrane; membrane; exocyst; cytoplasm; perinuclear region of cytoplasm; Flemming body;
Biological process	protein transport; exocyst localization; Golgi to plasma membrane transport; regulation of macroautophagy; phosphatidylinositol-mediated signaling; positive regulation of protein secretion; exocytosis; transport; viral process; defense response to virus;
	Sources:Amigo / QuickGO
Orthologs
	55763
	69940
	ENSG00000090989
	ENSMUSG00000036435
	Q9NV70
	Q8R3S6
	NM_001024924; NM_018261; NM_178237
NM_001289770; NM_001289771; NM_027270; NM_001359370; NM_001359372;
	NM_001359373
	NP_001020095; NP_060731; NP_839955
NP_001276699; NP_001276700; NP_081546; NP_001346299; NP_001346301;
	NP_001346302; NP_001388254; NP_001388255
	Wikidata
View/Edit Human	View/Edit Mouse

Exocyst complex component 1 is a protein that in humans is encoded by the EXOC1 gene.

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described.