EXOC2

EXOC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HK6
Identifiers
Aliases	EXOC2, SEC5, SEC5L1, Sec5p, exocyst complex component 2, NEDFACH
External IDs	OMIM: 615329; MGI: 1913732; HomoloGene: 10122; GeneCards: EXOC2; OMA:EXOC2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	693,139 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	31,158,076 bp
RNA expression pattern
	Top expressed in
	testicle; ; middle temporal gyrus; ; gonad; ; secondary oocyte; ; Brodmann area 23; ; islet of Langerhans; ; ganglionic eminence; ; Achilles tendon; ; stromal cell of endometrium; ; primary visual cortex;
	Top expressed in
	hand; ; genital tubercle; ; otolith organ; ; utricle; ; superior cervical ganglion; ; granulocyte; ; zygote; ; spermatocyte; ; spermatid; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein kinase binding; protein N-terminus binding;
Cellular component	cytosol; plasma membrane; exocyst; membrane; Flemming body;
Biological process	protein transport; regulation of entry of bacterium into host cell; Golgi to plasma membrane transport; exocyst assembly; exocytosis; transport; vesicle-mediated transport;
	Sources:Amigo / QuickGO
Orthologs
	55770
	66482
	ENSG00000112685
	ENSMUSG00000021357
	Q96KP1
	Q9D4H1
	NM_018303
	NM_025588; NM_001360093
	NP_060773
	NP_079864; NP_001347022
	Wikidata
View/Edit Human	View/Edit Mouse

Exocyst complex component 2 is a protein that in humans is encoded by the EXOC2 gene.

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts.