EXOC7

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Exo70 exocyst complex subunit
Exo70 exocyst complex subunit
	crystal structure of the s. cerevisiae exocyst component exo70p
Identifiers
Symbol	Exo70
Pfam	PF03081
Pfam clan	CL0295
InterPro	IPR004140
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

EXOC7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PFT
Identifiers
Aliases	EXOC7, 2-5-3p, EX070, EXO70, EXOC1, Exo70p, YJL085W, exocyst complex component 7, BLOM4, NEDSEBA
External IDs	OMIM: 608163; MGI: 1859270; HomoloGene: 41019; GeneCards: EXOC7; OMA:EXOC7 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,121,576 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,198,059 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; ganglionic eminence; ; parotid gland; ; ventricular zone; ; right lobe of thyroid gland; ; stromal cell of endometrium; ; external globus pallidus; ; pituitary gland; ; right hemisphere of cerebellum; ; left lobe of thyroid gland;
	Top expressed in
	triceps brachii muscle; ; spermatocyte; ; spermatid; ; superior frontal gyrus; ; ventricular zone; ; muscle of thigh; ; primary visual cortex; ; temporal muscle; ; neural layer of retina; ; neural tube;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; plasma membrane; growth cone membrane; exocyst; centriolar satellite; membrane; microtubule organizing center; Flemming body;
Biological process	protein transport; regulation of entry of bacterium into host cell; regulation of macroautophagy; exocytosis; transport;
	Sources:Amigo / QuickGO
Orthologs
	23265
	53413
	ENSG00000182473
	ENSMUSG00000020792
	Q9UPT5
	O35250
NM_001013839; NM_001145297; NM_001145298; NM_001145299; NM_001282313;
	NM_001282314; NM_015219; NM_001375974; NM_001375975; NM_001375976
NM_001162872; NM_016857; NM_001347636; NM_001362838; NM_001362839;
	NM_001378960; NM_001378961
NP_001013861; NP_001138769; NP_001138770; NP_001138771; NP_001269242;
	NP_001269243; NP_056034; NP_001362903; NP_001362904; NP_001362905
NP_001156344; NP_001334565; NP_058553; NP_001349767; NP_001349768;
	NP_001365889; NP_001365890
	Wikidata
View/Edit Human	View/Edit Mouse

Exocyst complex component 7 is a protein that in humans is encoded by the EXOC7 gene. It was formerly known as Exo70.

It forms one subunit of the exocyst complex. First discovered in Saccharomyces cerevisiae, this and other exocyst proteins have been observed in several other eukaryotes, including humans. In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localised at the tip of the bud, the major site of exocytosis in yeast. It interacts with the Rho3 GTPase. This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud). In humans, the functions of this protein and the exocyst complex are less well characterised: this protein is expressed in several tissues and is thought to also be involved in exocytosis.