Exosome component 10

EXOSC10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CPR, 3SAF, 3SAG, 3SAH
Identifiers
Aliases	EXOSC10, PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4, exosome component 10
External IDs	OMIM: 605960; MGI: 1355322; HomoloGene: 31105; GeneCards: EXOSC10; OMA:EXOSC10 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	11,099,869 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	148,666,858 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; tibial nerve; ; sural nerve; ; Achilles tendon; ; left ovary; ; right ovary; ; body of uterus; ; canal of the cervix; ; right uterine tube;
	Top expressed in
	genital tubercle; ; tail of embryo; ; seminiferous tubule; ; maxillary prominence; ; mandibular prominence; ; fetal liver hematopoietic progenitor cell; ; spermatocyte; ; otic placode; ; neural tube; ; otic vesicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; exoribonuclease activity; protein binding; catalytic activity; 3'-5' exonuclease activity; nucleic acid binding; nuclease activity; exonuclease activity; hydrolase activity; RNA binding; 3'-5'-exoribonuclease activity; telomerase RNA binding; single-stranded RNA binding;
Cellular component	cytoplasm; exosome (RNase complex); membrane; nuclear exosome (RNase complex); intracellular anatomical structure; nucleolus; nucleus; nucleoplasm; cytosol;
Biological process	RNA processing; nuclear polyadenylation-dependent rRNA catabolic process; nucleic acid phosphodiester bond hydrolysis; CUT catabolic process; nuclear-transcribed mRNA catabolic process; nuclear mRNA surveillance; cell metabolism; maturation of 5.8S rRNA; histone mRNA catabolic process; dosage compensation by inactivation of X chromosome; nucleobase-containing compound metabolic process; rRNA processing; RNA phosphodiester bond hydrolysis, exonucleolytic; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; negative regulation of telomere maintenance via telomerase; regulation of telomerase RNA localization to Cajal body; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nuclear polyadenylation-dependent snoRNA catabolic process; nuclear polyadenylation-dependent snRNA catabolic process; nuclear polyadenylation-dependent tRNA catabolic process; nuclear polyadenylation-dependent CUT catabolic process; nuclear polyadenylation-dependent antisense transcript catabolic process; polyadenylation-dependent snoRNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	5394
	50912
	ENSG00000171824
	ENSMUSG00000017264
	Q01780
	P56960
	NM_001001998; NM_002685
	NM_016699; NM_001355489; NM_001355490
	NP_001001998; NP_002676
	NP_057908; NP_001342418; NP_001342419
	Wikidata
View/Edit Human	View/Edit Mouse

Exosome component 10, also known as EXOSC10, is a human gene, the protein product of which (sometimes called PM/Scl-100) is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.