Exosome component 2

EXOSC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Identifiers
Aliases	EXOSC2, RRP4, Rrp4p, hRrp4p, p7, Exosome component 2, SHRF
External IDs	OMIM: 602238; MGI: 2385133; HomoloGene: 6095; GeneCards: EXOSC2; OMA:EXOSC2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	130,707,288 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	31,571,361 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; gonad; ; Achilles tendon; ; cerebellar hemisphere; ; left ovary; ; granulocyte; ; right hemisphere of cerebellum; ; right ovary; ; rectum;
	Top expressed in
	embryo; ; molar; ; epiblast; ; blastocyst; ; yolk sac; ; embryo; ; morula; ; somite; ; ventricular zone; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	3'-5'-exoribonuclease activity; exoribonuclease activity; 7S RNA binding; protein binding; RNA binding;
Cellular component	cytoplasm; cytosol; exosome (RNase complex); nuclear exosome (RNase complex); cytoplasmic exosome (RNase complex); nucleus; nucleoplasm; nucleolus;
Biological process	nuclear polyadenylation-dependent tRNA catabolic process; nuclear polyadenylation-dependent rRNA catabolic process; regulation of mRNA stability; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; CUT catabolic process; positive regulation of cell growth; exonucleolytic catabolism of deadenylated mRNA; rRNA processing; U4 snRNA 3'-end processing; polyadenylation-dependent snoRNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	23404
	227715
	ENSG00000130713
	ENSMUSG00000039356
	Q13868
	Q8VBV3
	NM_001282708; NM_001282709; NM_014285
	NM_144886
	NP_001269637; NP_001269638; NP_055100
	NP_659135
	Wikidata
View/Edit Human	View/Edit Mouse

Exosome component 2, also known as EXOSC2, is a protein which in humans is encoded by the EXOSC2 gene.