EXTL2

EXTL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OMX, 1OMZ, 1ON6, 1ON8
Identifiers
Aliases	EXTL2, EXTR2, exostosin-like glycosyltransferase 2, exostosin like glycosyltransferase 2
External IDs	OMIM: 602411; MGI: 1889574; HomoloGene: 1102; GeneCards: EXTL2; OMA:EXTL2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	100,895,179 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	115,822,666 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; postcentral gyrus; ; Brodmann area 46; ; lateral nuclear group of thalamus; ; ventricular zone; ; right adrenal cortex; ; superior frontal gyrus; ; left adrenal gland; ; left adrenal cortex; ; stromal cell of endometrium;
	Top expressed in
	facial motor nucleus; ; motor neuron; ; substantia nigra; ; anterior horn of spinal cord; ; lobe of cerebellum; ; cerebellar vermis; ; pineal gland; ; habenula; ; deep cerebellar nuclei; ; medial vestibular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; metal ion binding; glycosyltransferase activity; glycosaminoglycan binding; manganese ion binding; alpha-1,4-N-acetylgalactosaminyltransferase activity; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;
Cellular component	integral component of membrane; extracellular region; endoplasmic reticulum; membrane; endoplasmic reticulum membrane;
Biological process	heparan sulfate proteoglycan biosynthetic process; N-acetylglucosamine metabolic process; UDP-N-acetylgalactosamine metabolic process; IRE1-mediated unfolded protein response; protein glycosylation;
	Sources:Amigo / QuickGO
Orthologs
	2135
	58193
	ENSG00000162694
	ENSMUSG00000027963
	Q9UBQ6
	Q9ES89
	NM_001033025; NM_001261440; NM_001261441; NM_001261442; NM_001439
	NM_001163514; NM_001163515; NM_021388
	NP_001028197; NP_001248369; NP_001248370; NP_001248371; NP_001430
	NP_001156986; NP_001156987; NP_067363
	Wikidata
View/Edit Human	View/Edit Mouse

Exostosin-like 2 is a protein that in humans is encoded by the EXTL2 gene. EXTL2 Glycosyltransferase is required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. (https://www.phosphosite.org/overviewExecuteAction?id=5020882)