Eyes absent homolog 4

EYA4
Identifiers
Aliases	EYA4, CMD1J, DFNA10, EYA transcriptional coactivator and phosphatase 4
External IDs	OMIM: 603550; MGI: 1337104; HomoloGene: 3025; GeneCards: EYA4; OMA:EYA4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	133,532,128 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	23,350,786 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; seminal vesicula; ; gastrocnemius muscle; ; Achilles tendon; ; Skeletal muscle tissue of rectus abdominis; ; mucosa of paranasal sinus; ; muscle of thigh; ; bronchial epithelial cell; ; right ventricle;
	Top expressed in
	vestibular sensory epithelium; ; vestibular membrane of cochlear duct; ; olfactory epithelium; ; triceps brachii muscle; ; spermatid; ; sternocleidomastoid muscle; ; body of femur; ; temporal muscle; ; ankle; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; phosphoprotein phosphatase activity; hydrolase activity; metal ion binding; protein tyrosine phosphatase activity;
Cellular component	cytoplasm; nucleus;
Biological process	multicellular organism development; anatomical structure morphogenesis; peptidyl-tyrosine dephosphorylation; regulation of transcription, DNA-templated; hearing; DNA repair; transcription, DNA-templated; visual perception; cellular response to DNA damage stimulus; positive regulation of DNA repair; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; cell differentiation; chromatin organization; anatomical structure development;
	Sources:Amigo / QuickGO
Orthologs
	2070
	14051
	ENSG00000112319
	ENSMUSG00000010461
	O95677
	Q9Z191
NM_001301012; NM_001301013; NM_004100; NM_172103; NM_172104;
	NM_172105; NM_001370458; NM_001370459
	NM_010167; NM_001347372
NP_001287941; NP_001287942; NP_004091; NP_742101; NP_742103;
	NP_001357387; NP_001357388
	NP_001334301; NP_034297
	Wikidata
View/Edit Human	View/Edit Mouse

Eyes absent homolog 4 is a protein that in humans is encoded by the EYA4 gene.

This gene encodes a member of the eyes absent (EYA) subfamily of proteins. The encoded protein may act as a transcriptional activator and be important for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant nonsyndromic sensorineural 10 locus. Three transcript variants encoding distinct isoforms have been identified for this gene.