Ebastine

Ebastine
	Above: molecular structure of ebastine Below: 3D representation of an ebastine molecule
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	R06AX22 (WHO) ;
Pharmacokinetic data
Protein binding	Greater than 95%
Metabolism	Hepatic (CYP3A4-mediated), to carebastine
Elimination half-life	15 to 19 hours (carebastine)
Identifiers
	IUPAC name 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one;
CAS Number	90729-43-4 ;
PubChem CID	3191;
ChemSpider	3079 ;
UNII	TQD7Q784P1;
ChEMBL	ChEMBL305660 ;
CompTox Dashboard (EPA)	DTXSID6046472 ;
ECHA InfoCard	100.106.831
Chemical and physical data
Formula	C32H39NO2
Molar mass	469.669 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1ccc(cc1)C(C)(C)C)CCCN4CCC(OC(c2ccccc2)c3ccccc3)CC4;
	InChI InChI=1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3 ; Key:MJJALKDDGIKVBE-UHFFFAOYSA-N ;
	(verify)

Ebastine is a H₁ antihistamine with low potential for causing drowsiness.

It does not penetrate the blood–brain barrier to a significant amount and thus combines an effective block of the H₁ receptor in peripheral tissue with a low incidence of central side effects, i.e. seldom causing sedation or drowsiness.

It was patented in 1983 by Almirall S.A and came into medical use in 1990. The substance is often provided in micronised form due to poor water solubility.

Clinical data

Above: molecular structure of ebastine Below: 3D representation of an ebastine molecule
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	R06AX22 (WHO)
Pharmacokinetic data
Protein binding	Greater than 95%
Metabolism	Hepatic (CYP3A4-mediated), to carebastine
Elimination half-life	15 to 19 hours (carebastine)
Identifiers
IUPAC name 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one
CAS Number	90729-43-4^Y
PubChem CID	3191
ChemSpider	3079^Y
UNII	TQD7Q784P1
ChEMBL	ChEMBL305660^Y
CompTox Dashboard (EPA)	DTXSID6046472
ECHA InfoCard	100.106.831
Chemical and physical data
Formula	C₃₂H₃₉NO₂
Molar mass	469.669 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(c1ccc(cc1)C(C)(C)C)CCCN4CCC(OC(c2ccccc2)c3ccccc3)CC4
InChI InChI=1S/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3^Y Key:MJJALKDDGIKVBE-UHFFFAOYSA-N^Y
(verify)