"El Pañuelo" (English: "The Handkerchief") is a song recorded by American singer Romeo Santos alongside Spanish singer and songwriter Rosalía. It was released on 2 September 2022 through Sony Latin as the third single of Santos' fifth studio album Formula, Vol. 3 (2022). The song, a bachata, was written and produced by both performers alongside Diego el Cigala, Alexander Caba, Joaquín Díaz and Ramón Jiménez. It samples and interpolates the 1985 track "No Sé Qué Hacer", performed by Carlos Manuel "El Zafiro".