Elastin

ELN
Identifiers
Aliases	ELN, SVAS, WBS, WS, elastin, ADCL1
External IDs	OMIM: 130160; MGI: 95317; GeneCards: ELN; OMA:ELN - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	74,069,907 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	134,776,177 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; right coronary artery; ; right lung; ; popliteal artery; ; tibial arteries; ; gastric mucosa; ; left coronary artery; ; right auricle of heart; ; upper lobe of left lung;
	Top expressed in
	ascending aorta; ; aortic valve; ; left lung lobe; ; external carotid artery; ; tunica media of zone of aorta; ; internal carotid artery; ; optic nerve; ; umbilical cord; ; lactiferous gland; ; atrioventricular valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	extracellular matrix structural constituent; protein binding; extracellular matrix constituent conferring elasticity; extracellular matrix binding;
Cellular component	extracellular region; elastic fiber; extracellular matrix; collagen-containing extracellular matrix;
Biological process	animal organ morphogenesis; cell population proliferation; extracellular matrix disassembly; extracellular matrix organization; blood circulation; respiratory gaseous exchange by respiratory system; outflow tract morphogenesis; aortic valve morphogenesis; skeletal muscle tissue development; regulation of actin filament polymerization; stress fiber assembly; regulation of smooth muscle cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	2006
	13717
	ENSG00000049540
	ENSMUSG00000029675
	P15502
	P54320
NM_000501; NM_001081752; NM_001081753; NM_001081754; NM_001081755;
	NM_001278912; NM_001278913; NM_001278914; NM_001278915; NM_001278916; NM_001278917; NM_001278918; NM_001278939
	NM_007925
NP_000492; NP_001075221; NP_001075222; NP_001075223; NP_001075224;
	NP_001265841; NP_001265842; NP_001265843; NP_001265844; NP_001265845; NP_001265846; NP_001265847; NP_001265868
	NP_031951
	Wikidata
View/Edit Human	View/Edit Mouse

Elastin is a protein encoded by the ELN gene in humans and several other animals. Elastin is a key component in the extracellular matrix of gnathostomes (jawed vertebrates). It is highly elastic and present in connective tissue of the body to resume its shape after stretching or contracting. Elastin helps skin return to its original position whence poked or pinched. Elastin is also in important load-bearing tissue of vertebrates and used in places where storage of mechanical energy is required.