Vesicle-associated membrane protein 8

VAMP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WY4
Identifiers
Aliases	VAMP8, EDB, VAMP-8, vesicle associated membrane protein 8
External IDs	OMIM: 603177; MGI: 1336882; HomoloGene: 37846; GeneCards: VAMP8; OMA:VAMP8 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,582,031 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	72,367,686 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; monocyte; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; granulocyte; ; jejunal mucosa; ; rectum; ; nasal epithelium; ; bronchial epithelial cell; ; skin of abdomen;
	Top expressed in
	proximal tubule; ; right kidney; ; yolk sac; ; granulocyte; ; lung; ; bone marrow; ; human kidney; ; urinary bladder; ; duodenum; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SNAP receptor activity; protein binding; chloride channel inhibitor activity; SNARE binding;
Cellular component	cytoplasm; integral component of membrane; recycling endosome; vesicle; cytosol; endosome; early endosome membrane; membrane; secretory granule membrane; late endosome membrane; plasma membrane; mucin granule; lysosomal membrane; SNARE complex; early endosome; perinuclear region of cytoplasm; lysosome; extracellular exosome; clathrin-coated vesicle membrane; phagocytic vesicle membrane; azurophil granule membrane; specific granule membrane; recycling endosome membrane; tertiary granule membrane; synaptic vesicle;
Biological process	post-Golgi vesicle-mediated transport; autophagy; autophagosome maturation; negative regulation of secretion by cell; protein transport; viral entry into host cell; vesicle fusion; eosinophil degranulation; vesicle-mediated transport; mucus secretion; regulation of protein localization to plasma membrane; positive regulation of histamine secretion by mast cell; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; autophagosome membrane docking; neutrophil degranulation; membrane organization; regulation of molecular function; transport;
	Sources:Amigo / QuickGO
Orthologs
	8673
	22320
	ENSG00000118640
	ENSMUSG00000050732
	Q9BV40
	O70404
	NM_003761
	NM_016794
	NP_003752
	NP_058074
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex. Phosphorylation of VAMP8 inside the conserved SNARE-domain can suppress vesicle fusion.