Epithelial cell adhesion molecule

EPCAM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MZV
Identifiers
Aliases	EPCAM, DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1, epithelial cell adhesion molecule, BerEp4, MOC-31, Ber-Ep4
External IDs	OMIM: 185535; MGI: 106653; HomoloGene: 1764; GeneCards: EPCAM; OMA:EPCAM - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	47,387,601 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	87,958,557 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of colon; ; mucosa of sigmoid colon; ; rectum; ; duodenum; ; mucosa of transverse colon; ; renal medulla; ; corpus epididymis; ; islet of Langerhans; ; bronchial epithelial cell;
	Top expressed in
	left colon; ; ileum; ; migratory enteric neural crest cell; ; crypt of lieberkuhn of small intestine; ; epithelium of small intestine; ; intestinal villus; ; duodenum; ; vestibular sensory epithelium; ; utricle; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; protein binding; cadherin binding involved in cell-cell adhesion;
Cellular component	integral component of membrane; lateral plasma membrane; membrane; bicellular tight junction; plasma membrane; cell surface; cell junction; basolateral plasma membrane; apical plasma membrane; extracellular exosome; integral component of plasma membrane;
Biological process	ureteric bud development; positive regulation of cell motility; negative regulation of cell-cell adhesion mediated by cadherin; signal transduction involved in regulation of gene expression; negative regulation of apoptotic process; stem cell differentiation; positive regulation of cell population proliferation; positive regulation of stem cell proliferation; positive regulation of transcription by RNA polymerase II; leukocyte migration; cell-cell adhesion via plasma-membrane adhesion molecules;
	Sources:Amigo / QuickGO
Orthologs
	4072
	17075
	ENSG00000119888
	ENSMUSG00000045394
	P16422
	Q99JW5
	NM_002354
	NM_008532
	NP_002345
	NP_032558
	Wikidata
View/Edit Human	View/Edit Mouse

Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca²⁺-independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.