Estradiol hemisuccinate

Estradiol hemisuccinate
Clinical data
Trade names	Eutocol, Hosterona (with progesterone)
Other names	Estradiol succinate; Estradiol 17β-hemisuccinate; Estradiol 17β-succinate
Routes of; administration	By mouth, intramuscular injection
Drug class	Estrogen; Estrogen ester
Identifiers
	IUPAC name 4-{[(17β)-3-Hydroxyestra-1,3,5(10)-trien-17-yl]oxy}-4-oxobutanoic acid;
CAS Number	7698-93-3;
PubChem CID	66440;
PubChem SID	99444362;
DrugBank	DB07891;
ChemSpider	59813;
UNII	VQV5064VG6;
ChEMBL	ChEMBL1233274;
PDB ligand	HE7 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID00227770 ;
ECHA InfoCard	100.163.857
Chemical and physical data
Formula	C22H28O5
Molar mass	372.461 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CC[C@@H]3c4ccc(cc4CC[C@H]3[C@@H]1CC[C@@H]2OC(=O)CCC(=O)O)O;
	InChI InChI=1S/C22H28O5/c1-22-11-10-16-15-5-3-14(23)12-13(15)2-4-17(16)18(22)6-7-19(22)27-21(26)9-8-20(24)25/h3,5,12,16-19,23H,2,4,6-11H2,1H3,(H,24,25)/t16-,17-,18+,19+,22+/m1/s1; Key:YJPIDPAGJSWWBE-FNIAAEIWSA-N;

Estradiol hemisuccinate (brand name Eutocol), or simply estradiol succinate, also known as estradiol 17β-hemisuccinate, is an estrogen medication and an estrogen ester – specifically, the hemisuccinate ester of estradiol. It is used as a component of hormone replacement therapy for menopause. Like other estrogens, estradiol hemisuccinate has been found to have beneficial effects on the skin, with improvement of skin thickness observed.

Estradiol hemisuccinate is also a component of estradiol hemisuccinate/progesterone (brand name Hosterona), an injectable preparation used to induce withdrawal bleeding in women with amenorrhea.