Estrogen-related receptor beta

ESRRB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LO1
Identifiers
Aliases	ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2, estrogen related receptor beta, ERRbeta2, ERR beta-2, Esrrb
External IDs	OMIM: 602167; MGI: 1346832; HomoloGene: 69108; GeneCards: ESRRB; OMA:ESRRB - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	76,501,837 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	86,568,402 bp
RNA expression pattern
	Top expressed in
	testicle; ; human kidney; ; muscle of thigh; ; apex of heart; ; gastrocnemius muscle; ; left ventricle; ; renal medulla; ; body of stomach; ; right auricle of heart; ; skeletal muscle tissue;
	Top expressed in
	neural layer of retina; ; stria vascularis; ; chorion; ; retinal pigment epithelium; ; vestibular sensory epithelium; ; morula; ; lumbar subsegment of spinal cord; ; blastocyst; ; secondary oocyte; ; ooblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	steroid binding; nuclear receptor activity; zinc ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; transcription factor binding; metal ion binding; steroid hormone receptor activity; transcription coactivator activity; protein binding; RNA polymerase II complex binding; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;
Cellular component	nucleus; nucleoplasm; condensed chromosome; integrator complex; chromosome; cytoplasm;
Biological process	regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; embryonic placenta development; transcription, DNA-templated; steroid hormone mediated signaling pathway; transcription initiation from RNA polymerase II promoter; intracellular receptor signaling pathway; stem cell population maintenance; negative regulation of transcription by RNA polymerase II; cell population proliferation; stem cell division; cell dedifferentiation; photoreceptor cell maintenance; positive regulation of transcription, DNA-templated; inner ear development; positive regulation of transcription involved in G1/S transition of mitotic cell cycle; positive regulation of transcription involved in G2/M transition of mitotic cell cycle; positive regulation of stem cell population maintenance; regulation of stem cell division; negative regulation of stem cell differentiation; positive regulation of glycogen biosynthetic process; positive regulation of glycolytic process;
	Sources:Amigo / QuickGO
Orthologs
	2103
	26380
	ENSG00000119715
	ENSMUSG00000021255
	O95718
	Q61539
	NM_004452; NM_001379180
	NM_001159500; NM_011934
	NP_004443; NP_001366109
	NP_001152972; NP_036064
	Wikidata
View/Edit Human	View/Edit Mouse

Estrogen-related receptor beta (ERR-β), also known as ESRRB or NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (Estrogen Related Receptor Beta) gene .