Etilefrine
| Clinical data | |
|---|---|
| Trade names | Effortil, many others |
| Other names | Etilephrine; Ethylnorphenylephrine; Ethylphenephrine; Ethyladrianol; Etiladrianol; Aethyladrianol; M-I-36; 3,β-Dihydroxy-N-ethylphenethylamine; 3,β-Dihydroxy-N-ethyl-β-phenylethylamine |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral, injection |
| Drug class | Adrenergic receptor agonist; Sympathomimetic |
| ATC code | |
| Pharmacokinetic data | |
| Bioavailability | Oral: 50% |
| Protein binding | 23% (8.5% to albumin) |
| Metabolism | Conjugation (glucuronidation) |
| Metabolites | • Conjugates • Hydroxymandelic acid (3%) |
| Elimination half-life | 2.5 hours |
| Excretion | Urine (80%; 7–28% unchanged, 44–73% as conjugates) |
| Identifiers | |
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| DrugBank | |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.010.829 |
| Chemical and physical data | |
| Formula | C10H15NO2 |
| Molar mass | 181.235 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
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Etilefrine, sold under the brand name Effortil among others, is a sympathomimetic medication used as an antihypotensive agent to treat orthostatic hypotension. It is usually used by mouth, but is also available as an injectable.
Side effects of etilefrine include nausea, tremors, and palpitations, among others. Etilefrine is an agonist of the α- and β-adrenergic receptors. It is a substituted phenethylamine and is related to epinephrine, phenylephrine, and norfenefrine.
Etilefrine was first described and introduced for medical use by 1949.