Exemestane
| Clinical data | |
|---|---|
| Pronunciation | /ˌɛksəˈmɛˌsteɪn/ EK-sə-ME-stayn |
| Trade names | Aromasin |
| Other names | FCE-24304 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a607006 |
| Routes of administration | By mouth |
| Drug class | Aromatase inhibitor; Antiestrogen |
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| Pharmacokinetic data | |
| Bioavailability | ~60% |
| Protein binding | 90% |
| Metabolism | Liver (CYP3A4, aldo-keto reductase) |
| Elimination half-life | 24 hours |
| Duration of action | 4–5 days |
| Excretion | Urine and feces ~ 1:1 (mainly metabolites) |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.171.149 |
| Chemical and physical data | |
| Formula | C20H24O2 |
| Molar mass | 296.410 g·mol−1 |
| 3D model (JSmol) | |
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| (what is this?) (verify) | |
Exemestane, sold under the brand name Aromasin among others, is a medication used to treat breast cancer. It is a member of the class of antiestrogens known as aromatase inhibitors. Some breast cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive, hormonally-responsive, or hormone-receptor-positive. Aromatase is an enzyme that synthesizes estrogen. Aromatase inhibitors block the synthesis of estrogen. This lowers the estrogen level, and slows the growth of cancers.