Protease-activated receptor 2

F2RL1
Identifiers
Aliases	F2RL1, GPR11, PAR2, Protease activated receptor 2, F2R like trypsin receptor 1
External IDs	OMIM: 600933; MGI: 101910; HomoloGene: 21087; GeneCards: F2RL1; OMA:F2RL1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	76,835,315 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	95,661,735 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; jejunal mucosa; ; skin of thigh; ; duodenum; ; kidney tubule; ; rectum; ; skin of hip; ; gingival epithelium; ; mucosa of ileum; ; mucosa of transverse colon;
	Top expressed in
	epithelium of stomach; ; vestibular membrane of cochlear duct; ; left colon; ; pineal gland; ; ileum; ; corneal stroma; ; mucous cell of stomach; ; pyloric antrum; ; jejunum; ; lip;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; thrombin-activated receptor activity; G-protein beta-subunit binding; protein binding; G-protein alpha-subunit binding; signaling receptor binding; signaling receptor activity;
Cellular component	integral component of membrane; Golgi apparatus; pseudopodium; membrane; plasma membrane; integral component of plasma membrane; early endosome;
Biological process	positive regulation of Rho protein signal transduction; establishment of endothelial barrier; thrombin-activated receptor signaling pathway; neutrophil activation; positive regulation of phagocytosis, engulfment; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of eosinophil degranulation; positive regulation of neutrophil mediated killing of gram-negative bacterium; negative regulation of tumor necrosis factor-mediated signaling pathway; immune system process; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration; blood coagulation; positive regulation of JNK cascade; positive regulation of leukocyte chemotaxis; negative regulation of JNK cascade; leukocyte proliferation; regulation of JNK cascade; positive regulation of pseudopodium assembly; positive regulation of renin secretion into blood stream; defense response to virus; positive regulation of chemotaxis; positive regulation of ERK1 and ERK2 cascade; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of superoxide anion generation; positive regulation of glomerular filtration; regulation of blood coagulation; inflammatory response; innate immune response; mature conventional dendritic cell differentiation; negative regulation of toll-like receptor 3 signaling pathway; positive regulation of actin filament depolymerization; leukocyte migration; regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; positive regulation of positive chemotaxis; signal transduction; T cell activation involved in immune response; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; cell-cell junction maintenance;
	Sources:Amigo / QuickGO
Orthologs
	2150
	14063
	ENSG00000164251
	ENSMUSG00000021678
	P55085
	P55086
	NM_005242
	NM_007974
	NP_005233
	NP_032000
	Wikidata
View/Edit Human	View/Edit Mouse

Protease activated receptor 2 (PAR2) also known as coagulation factor II (thrombin) receptor-like 1 (F2RL1) or G-protein coupled receptor 11 (GPR11) is a protein that in humans is encoded by the F2RL1 gene. PAR2 modulates inflammatory responses, obesity, metabolism, cancers and acts as a sensor for proteolytic enzymes generated during infection. In humans, we can find PAR2 in the stratum granulosum layer of epidermal keratinocytes. Functional PAR2 is also expressed by several immune cells such as eosinophils, neutrophils, monocytes, macrophages, dendritic cells, mast cells and T cells.