FAAH2

FAAH2
Identifiers
Aliases	FAAH2, AMDD, fatty acid amide hydrolase 2
External IDs	OMIM: 300654; HomoloGene: 45263; GeneCards: FAAH2; OMA:FAAH2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	57,489,193 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; body of pancreas; ; right lobe of liver; ; olfactory zone of nasal mucosa; ; pituitary gland; ; anterior pituitary; ; islet of Langerhans; ; skin of abdomen; ; skin of leg; ; minor salivary glands;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; fatty acid amide hydrolase activity;
Cellular component	integral component of membrane; lipid droplet; membrane;
Biological process	arachidonic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	158584
	n/a
	ENSG00000165591
	n/a
	Q6GMR7
	n/a
	NM_174912; NM_001353840; NM_001353841
	n/a
	NP_777572; NP_001340769; NP_001340770
	n/a
	Wikidata
View/Edit Human

Fatty acid amide hydrolase 2 or FAAH2 is a member of the serine hydrolase family of enzymes.

Fatty acid amide hydrolase 2 degrades many types of fatty acid amides, including the sleep-inducing oleamide and endocannabinoids such as anandamide. It has a tissue distribution quite distinct from the paralogous FAAH (or "FAAH1"). Compared to FAAH, it is less active on N-acyl ethanolamines (e.g. anandamide) and N-acyl taurines.

OrthoDB indicates that FAAH2 (as a gene distinct from FAAH) has orthologs all across Metazoa, with the notable exclusion of rodents. This complicates the translation of FAAH-related results from rodent models to human biology.